Uninstalling a program on a Mac. Begin by exiting out of all programs that are running. Next open the “Applications” folder by clicking on the hard disk icon. Drag the icon that you wish to remove over to the trash bin. Proceed to empty the trash. This will usually work on most applications however, some will be more difficult – especially if there are related program files in different folders. In that case it is best to check the program’s documentation for an uninstall tool. Usually these tools will find and remove all of the files associated with the program.